Lead Sponsor

University of Utah

Age

0 - 0 years

Sex

ALL

Healthy Volunteers

No

•Infants born prematurely at \< or = 28 weeks gestation requiring invasive (mechanical ventilation) or non-invasive positive pressure support (nasal continuous positive airway pressure, high flow nasal cannula \>1 lpm) and FiO2 of at least 0.30 at 32 +/- 1 weeks postmenstrual age
•2.Tolerating at least one-half of full volume oral/gavage tube feedings (using 120 ml/kg/d as full volume oral/gavage tube feedings)
•3.The continuous need for some form of respiratory support (supplemental oxygen, flow) for the prior 14 days
•4.Hemoglobin \> 10 mg/dL

•1. Known major fetal anomaly or chromosomal aneuploidy
•2. Clinical evidence of congenital heart disease (except patent ductus arteriosus (PDA), atrial septal defect (ASD), or ventricular septal defect (VSD)
•3. Urine output \< 1 ml/kg/hr
•4. History of or known to have liver failure
•5. History of or known to have necrotizing enterocolitis
•6. History of or known to have significant feeding intolerance beyond the first week of life
•7. Presence of any acute illness defined by fever \>100.4 F, vomiting, or diarrhea
•8. Hemoglobin \< 10 mg/dL
•9. Neonatal Intensive Care Unit (NICU) cases determined to be futile (anticipated death prior to hospital discharge)
•10. Multiple births