Heritability of Polycystic Ovary Syndrome: Role of Antimullerian Hormone, Steroids and Leptin

Inclusion Criteria

• •Having a pre-conceptional infertility assessment in the gynecology-Endocrinology department of University Hospital of Lille
• •in the first trimester of mono fetal pregnancy (between 5 and 10 weeks of gestation), obtained spontaneously, after induction of ovulation or Assisted Reproductive Techniques (ART)
• •Pregnancy followed at University Hospital of Lille
• •PCOS group: defined according to modified Rotterdam criteria (2003 and 2011)
• •At least 2 of the following 3 criterion:
• •* Cycle disorder
• •* Clinical and / or biological hyperandrogenism
• •* Ovarian volume \> 10cm³ and/or more than 19 follicles from 2 to 9 mm per ovary
• •After exclusion of other causes of cycle disorder or hyperandrogenism
• •Control group: patient with severe male and / or tubal infertility, no cycling disorder, normal ovarian reserve (FSH\<10 IU / L, E2\<50 pg / ml, AMH\>7 and \<35 pmol / L and Follicles count between \>5 and \<20 per ovary at day 3 of the cycle).
• •In the group of female controls, the fertility problem is not related to a female pathology of the hypothalamic-pituitary-ovarian axis (tubal or male infertility). They are women without ovarian personal pathology. The problem of fertility being of other origin.