A Comparative Study of the Effects of QS-M Needle Free Injector and Glargine Pen Subcutaneous Injection of Insulin Glargine on Insulin Use

Exclusion Criteria

• •1. there is conflict of interest with this research.
• •2. blood glucose control is not good enough to participate in this study, such as repeated hypoglycemia, diabetic ketoacidosis or hyperosmolar coma.
• •3. serious diabetic complications such as diabetic foot, diabetic nephropathy and so on;
• •4. severe cardiovascular events occurred in the last 6 months.
• •5. the application of hormone or immunosuppressant, or low immunity defect;
• •6. the use of non steroidal anti-inflammatory drugs;
• •7. the use of sulfonylureas and insulin secreting agents;
• •8. a person with a history of cancer;
• •9. a history of unstable or rapid progressive renal disease;
• •10. an unstable history of major mental illness;
• •11. the history of hemoglobin (such as sickle red cell anemia, thalassemia, iron granulocytic anemia);
• •12. women who are pregnant or are breastfeeding;
• •13. in the near future there is a clear infection, such as urinary tract infection and pneumonia;
• •14. recent important visceral hemorrhage, such as gastric hemorrhage and cerebral hemorrhage, etc.
• •15. skin diseases such as exfoliative dermatitis, pustular sore and infection of pyogenic bacteria;
• •16. the history of acute pancreatitis or pancreatectomy;
• •17. the researchers believe that it may lead to any situation in which the subject is unable to complete the study or may cause significant risk to the subject.
• •18. the results of the laboratory examination are as follows: A. obvious abnormal liver function or in the active phase of the disease (AST\> 3 times the upper limit of normal ALT\> or 3 times the upper limit of normal); The creatinine clearance rate of B. was \<60ml/min; C. anaemia caused by any cause of the disease; The results of pregnancy test in women of childbearing age of D. were positive.