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Abdominal closure with antibacterial-coated sutures has been shown to reduce wound infections after a number of surgical procedures, but none of the previous trials included cesarean delivery. Our objective is to determine whether use of antibacterial-coated sutures reduces surgical site infection (SSI) after cesarean delivery.
A review of 18 studies demonstrated a significant benefit of antimicrobial coated sutures in reducing SSI (RCTs: OR 0.72; 95% CI 0.59-0.88; observational studies: OR 0.58; 95% CI 0.40-0.83). As there are no clinical trials focusing on cesarean delivery, and because the risk factors and pathogenesis for post-cesarean SSI may not mirror other procedures, further data is needed before generalizing the WHO recommendations to cesarean procedures.
Age
18 - 50 years
Sex
FEMALE
Healthy Volunteers
No
University of Texas Medical Branch in Galveston
Galveston, Texas, United States
Start Date
January 9, 2018
Primary Completion Date
November 22, 2024
Completion Date
November 22, 2024
Last Updated
January 6, 2025
1,122
ACTUAL participants
Vicryl-plus, monocryl-plus, PDS-plus (Triclosan-coated Sutures)
DRUG
Vicryl, monocryl, PDS (not coated with triclosan)
OTHER
Lead Sponsor
The University of Texas Medical Branch, Galveston
NCT07379684
NCT03561376
Data Source & Attribution
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