Repetitive Transcranial Magnetic Stimulation as a Treatment for Pain in Parkinson's Disease

Exclusion Criteria

• •Patients will be excluded from the trial if they:
• •1. Are suffering from pain not attributable from Parkinson's Disease
• •2. Are suffering from any neurological or psychiatric disease that could interfere with provision of reliable data (dementia, major depression, drug abuse, alcoholism)
• •3. Are suffering from a rapidly progressing malignant disease or other systemic disease that is likely to significantly interfere with their participation in the study
• •4. Are candidates or have been listed for surgery or other major medical intervention requiring hospitalisation and/or rehabilitation (e.g., hip replacement).
• •5. Have a history of seizures or epilepsy,
• •6. Require high doses of medication known to lower the threshold for seizures (e.g., amitriptyline \> 100mg/d,
• •7. Have cerebral space occupying lesion,
• •8. Have a history of severe head injury (associated with a suspicion of brain injury, e.g. resulting in unconsciousness for over 24 hrs)
• •9. Have metal located in head (e.g. shrapnel, surgical clips, fragments from welding),
• •10. Have a cochlear implant,
• •11. Have a cardiac pacemaker in situ,
• •12. Have a deep brain or vagal nerve stimulator in situ,
• •13. Are pregnant