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Verapamil for Neuroprotection in Stroke | Clinical Trials | Clareo Health

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RECRUITINGPhase 1/2NCT03347786

Verapamil for Neuroprotection in Stroke

The purpose of this research study is to test an experimental procedure called intra-arterial delivery of verapamil in patients diagnosed with acute ischemic stroke. This study investigates the safety...

Lead sponsor: Global Neurosciences Institute•3 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Global Neurosciences Institute

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Written informed consent
•18 years of age and over
•Acute onset focal neurologic deficit consistent with acute ischemic stroke, or computed tomographic scan consistent with acute cerebral ischemia
•Candidate for mechanical thrombectomy procedure
•Onset of symptoms less than 8 hours
•Measurable neurologic deficit (NIHSS ≥4)
•Willingness to follow up with rehabilitation therapy
•Anticipated life expectancy of at least 3 months

Exclusion Criteria

•Pregnancy or suspected pregnancy (pregnancy test will be done on women of child-bearing potential)
•Hepatic and/or renal insufficiency (LFT's\>3× upper limit of normal; CrCl \< 30ml/min)
•Thrombocytopenia (platelet count \<75,000/mm3)
•History of intolerance to verapamil
•Previous functional disability (modified Rankin \> 1)
•Severe stroke (NIHSS\>22)
•Stuporous or comatose
•Unlikely to be available for 90 day follow-up

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: January 17, 2025Terms

Trial snapshot

StatusRECRUITING

PhasePHASE1/PHASE2

Enrollment60

Start dateApr 2017

Last updatedJan 17, 2025

Condition

Ischemic Stroke

Locations shown

AtlantiCare Regional Medical Center

Atlantic City, New Jersey

St Mary Medical Center

Langhorne, Pennsylvania

Crozer Chester Medical Center

Upland, Pennsylvania

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 17, 2025Data synced to Clareo: April 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions