Naloxegol and Opioid-induced Constipation

Exclusion Criteria

• •Medically unstable
• •Cognitive deficits that impair the patient's ability to understand the informed consent
• •Language barriers
• •Patient has a documented diagnosis of one of the following: Crohn's disease; Ulcerative Colitis; History of bowel surgery that will impact absorption of study drug (as deemed by physician); History of small bowel obstruction
• •Chronic constipation requiring subject to take one of the following medications on a daily basis prior to time of consent: Linzess, Trulance, Amitza, Senna/Senokot, Colace, Dulcolax, Miralax, Metamucil
• •Patients on following medications prior to time of consent: Diltiazem, Verapamil, Amiodarone, Ketoconazole, Clarithromycin/ erythromycin, Antivirals
• •Conditions that present an increased risk of bowel perforation (as determined by the physician)
• •Pre-existing diagnosis of opioid-induced constipation AND receiving naloxegol as a treatment by their physician