Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Douglas Seals
Over, the proposed research project has the long-term potential to influence clinical practice by establishing a novel lifestyle intervention for treating multiple domains of age- and hypertension-associated physiological dysfunction and thereby reducing the risk of clinical disease and disability.
Age
50–64
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Ability to provide informed consent
Willing to accept random assignment to condition
Women will be confirmed as postmenopausal (either natural or surgical) based on cessation of menses for \>1 year.
Resting systolic blood pressure 120-159 mmHg
Resting diastolic blood pressure \<100 mmHg
Free from alcohol dependence or abuse, as defined by the American Psychiatry Association, Diagnostic and Statistical Manual or Mental Disorders (DSM-IV)
You may not be if
Current smoking
Chronic clinical disease (e.g., inflammatory bowel disease/irritable bowel syndrome, coronary artery/peripheral artery/cerebrovascular diseases, diabetes, chronic kidney disease requiring dialysis, neurological disorders or diseases that may affect motor/cognitive function \[multiple sclerosis, Parkinson's disease, polio, Alzheimer's disease, dementia, or other brain diseases of aging\]), except hypertension
Postmenopausal \<1 year
Scoring \<21 on the mini-mental state examination
Moderate or sever peripheral artery disease (ankle-brachial index 0.7)
Taking a medication that your doctor deems unsafe to hold for \>1 week
A graded exercise test will be performed by all subjects. If there is physician concern or an adverse event, the subject will not participate in the study.
No weight stable in the prior 3 months (\>2 kg weight change) or unwilling to remain weight stable throughout study (rationale: recent weight change or weight loss can influence vascular function)
Clareo Health | Inspiratory Muscle Strength Training to Improve Blood Pressure and Physiological Function
