A Study to Assess the Safety and Effectiveness of FLX-787 in Subjects With Charcot-Marie-Tooth Disease Experiencing Muscle Cramps.

Exclusion Criteria

• •Presence of major gastrointestinal disorders, such as inflammatory bowel disease, diverticulitis, active peptic ulcer disease, or significant gastroesophageal reflux disease (i.e., not well-controlled on antacids or proton pump inhibitors), or oral or esophageal lesions/ulcers
• •Presence of significant swallowing problems
• •Unable or unwilling to discontinue medications for cramps and/or opiates
• •Inability to tolerate a spicy sensation in the mouth or stomach
• •Actively using illicit drugs or history of chronic substance abuse within the past year prior to screening, including abuse of alcohol
• •Intention to change the current level of tobacco use or use of nicotine-containing products (i.e., new smokers or those actively trying to quit may not enrolled)
• •Participated in a clinical study (except natural history studies without administration of an investigational product) within 30 days prior to screening