Basal-bolus Insulin Therapy Versus Standard Therapy for the Inpatient Management of Type 2 Diabetes: the IDA2 Study

Exclusion Criteria

• •Hyperglycemia without known history of type 2 diabetes
• •Type 1 diabetes mellitus
• •Severely impaired renal function (eGFR ≤ 30 mL/min/1,73 m2)
• •Severe hepatic disease
• •Cardiac disease defined as: Decompensated heart failure (NYHA class III-IV) and/or diagnosis of unstable angina pectoris and/or myocardial infarction within the last 6 months
• •Pregnant or lactating women or fertile female patients not using chemical, hormonal or mechanical contraceptives or not in menopause (i.e. must not have had regular menstrual bleeding for at least one year)
• •Planned treatment during hospital stay with intravenous glucose/ insulin for ≥ 12 hours
• •Treatment at admission or planned treatment during hospital stay with parenteral nutrition or enteral nutrition (i.e. gastroenteric tube feeding)
• •Treatment at admission or planned treatment during hospital stay with high dose glucocorticoids (\>40 mg)
• •History or presence of malignancy (except basal skin cancer) unless a disease-free period exceeding five years
• •Presence of alcohol or drug abuse
• •Inability to understand the written information or incapability to provide informed consent