ALS Study Determining Various Biomarkers and Strength Comparison After Exercise

Inclusion Criteria

• •Diagnosis of possible, probable or definite amyotrophic lateral sclerosis (ALS) based on the revised El-Escorial criteria
• •Presence in ipsilateral leg of either weakness in any muscle group or of active denervation by needle electromyography (EMG) which is a surrogate marker of early denervation
• •Ipsilateral quadriceps femoris strength: \>=4
• •Ambulatory with or without assistance
• •Revised ALS Functional Rating Scale (ALSFRS-R) Score \> 30
• •Forced expiratory vital capacity (FVC) \>50% of predicted