A Substudy of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis

Exclusion Criteria

• •The participant has conditions that preclude a lumbar puncture (LP), such as:
• •* A history of clinically significant back pain, back pathology, and/or back injury (for example, degenerative disease, spinal deformity, or spinal surgery) that may predispose to complications or technical difficulty with LP.
• •* Allergy to local anesthetics, such as lidocaine or its derivatives.
• •* A local infection at the intended site of the LP.
• •* Less than 100 giga per liter \[(\<100 GI/L) is equivalent to 100,000 per cubic millimeter (100,000/mm³)\] platelets or clinically significant coagulation abnormality or significant active bleeding, or
• •* Currently receiving treatment with an anticoagulant, antiplatelet agent, or other drug that affects coagulation or platelet function. Low dose (according to local medical guidelines) aspirin is permitted.