Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Alabama at Birmingham
Age
18–99
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Moderate to severe asthma requiring medium to high dose inhaled corticosteroids
1. Patients will be recruited through the UAB Asthma Clinic and using the UAB Asthma Clinic Database for the Biospecimen Repository
2. Patients must show spirometry with positive bronchodilator reversibility or have a positive Methacholine Challenge Test within 3 years of enrollment
2. Obesity as defined as BMI over 30
3. Self-reported or radiographic evidence of gastroesophageal reflux disease
4. Ability and willingness to provide informed consent
You may not be if
1. Inability of the subject to provide informed consent
2. Inability of the subject to undergo bronchoscopy
3. Use of monoclonal antibody within three months prior to enrollment
4. Use of immunosuppressive medication
5. Use of oral corticosteroids or antibiotics 4 weeks prior to enrollment
6. Use of anticoagulants (warfarin/Coumadin and heparin products).
7. Use of aspirin and/or other non-steroidal anti-inflammatory drugs or clopidogrel (Plavix) within 5 days of bronchoscopy.
8. Pregnancy
9. Diagnosis of HIV, active cancer, or liver disease
Clareo Health | Oral Probiotic Administration to Modulate the Airway Microbiome in Obese Asthmatic Subjects
