Salicylic Augmentation in Depression

Exclusion Criteria

• •Active suicidal ideation
• •History of manic episodes or psychosis
• •Alcohol or substance use disorder up to one month prior to first testing session
• •Comorbid neurologic condition affecting the central nervous system
• •Comorbid autoimmune condition
• •Uncorrected thyroid disease or a current abnormal thyroid-stimulating hormone (TSH)
• •Active or recent (within the past month) infection (such as otitis, pneumonia, urinary tract infection); temperature \> 100.3 or white blood cell (WBC) count \> 11 K/microL will be considered evidence of active infection even in the absence of other symptoms
• •History of GI bleed
• •History of stroke
• •History of a bleeding disorder
• •Platelet count \< 150,000/mm3 on initial screening
• •On a blood-thinning agent or taking NSAIDs daily
• •Current use of oral steroids or other immunomodulating medications
• •Salicylate sensitivity
• •Pregnancy or breastfeeding