Accuracy of Methemoglobin Measurement for Rainbow Universal Pulse Oximeter Sensor

Exclusion Criteria

• •The subject is obese (BMI\>30).
• •The subject has a known history of heart disease, lung disease, kidney or liver disease.
• •Diagnosis of asthma, sleep apnea, or use of CPAP.
• •Subject has diabetes.
• •Subject has a clotting disorder.
• •The subject has a hemoglobinopathy or history of anemia, per subject report or the first blood sample, that in the opinion of the investigator, would make them unsuitable for study participation.
• •The subject has any other serious systemic illness.
• •The subject is a current smoker.
• •Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators' would interfere with the sensors working correctly.
• •The subject has a history of fainting or vasovagal response.
• •The subject has a history of sensitivity to local anesthesia or allergy to the study drugs.
• •The subject has a diagnosis of Raynaud's disease.
• •The subject has unacceptable collateral circulation based on exam by the investigator (Allen's test).
• •The subject is pregnant, lactating or trying to get pregnant.
• •The subject has a history of migraine headaches.
• •The subject is currently taking antidepressants.
• •The subject is unable or unwilling to provide informed consent, or is unable or unwilling to comply with study procedures.
• •The subject has any other condition, which in the opinion of the investigators' would make them unsuitable for the study.