Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Zurich
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Informed consent as documented by signature
age ≥ 18 years and able to give informed consent
≥ 12 months after renal transplantation
stable clinical condition
stable graft function over the last 3 months (creatinine changes ± 15%)
eGFR between 15-89 ml/min/1.73 m2
serum bicarbonate ≤ 22 mmol/l within the last 6 months
You may not be if
uncontrolled hypertension or use of \> 4 antihypertensive agents
uncontrolled heart failure
serum potassium \< 3.0 mmol/l
serum sodium \> 150 mmol/l
use of alkali in the preceding 4 weeks
use of mineralocorticoid antagonists, topiramate, carbo anhydrase inhibitors or any drugs with similar effects
history of noncompliance with clinic visits
hereditary fructose intolerance
known hypersensitivity or allergy to the drug used in this study or to peanut, sorbitol, and soy
pregnancy or breastfeeding
intention to become pregnant during the course of the study
lack of safe contraception, defined as: Female participants of childbearing potential, not using and not willing to continue using a medically reliable method of contraception for the entire study duration, such as oral, injectable, or implantable contraceptives, or intrauterine contraceptive devices, or who are not using any other method considered sufficiently reliable by the investigator in individual cases.
please note that female participants who are surgically sterilised / hysterectomised or post-menopausal for longer than 2 years are not considered as being of child bearing potential.
suspected drug or alcohol abuse
inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
enrolment of the investigator, his/her family members, employees and other dependent persons
