Evaluation of Children With Endocrine and Metabolic-Related Conditions

Study Description: This protocol is designed to allow endocrine-related evaluations of children with known or suspected endocrine or metabolic disorders. Children with endocrine or metabolic-related condition(s) who may or may not be eligible for a specific NICHD research protocol, may be evaluated under the auspices of this protocol. Standard clinically indicated laboratory or radiological studies may be performed to confirm a diagnosis or to aid in the management of the patient. In some cases, the child participant may receive medical or surgical treatment for their disorder at the National Institutes of Health (NIH) Clinical Center (CC) according to current clinical practice. Family members of children evaluated on this protocol (who have informative meiotic inheritance relationships to the proband or index case) may be enrolled in the genetic/DNA testing part of the protocol. Objectives: Primary Objective: -Comprehensive evaluation of pediatric endocrine diseases and conditions as well as track natural progress of the development of such conditions in diverse population of pediatric subjects with a known or suspected endocrine or metabolic disorder. Secondary Objective: -Samples for molecular genetic or WES testing Endpoints: Primary Endpoint: Appraisal of number and diversity of endocrine related diagnosis of patients evaluated on this protocol. Secondary Endpoints: -Number of samples for molecular genetic or WES testing.