PLUG Dementia Trial and MRI PLUG Dementia Sub-Study

Inclusion Criteria

• •1. Male or female \>65 years of age
• •2. Atrial fibrillation documented by electrocardiogram, ambulatory event monitor, or telemetry within 6 months of enrollment
• •3. Moderate risk of thromboembolism based upon a CHADS2 score or CHADS2 Vasc score of ≥2.
• •4. Recipient of a left atrial appendage closure device within 3 months of enrollment (within 6 months, for patients considered for the MRI PLUG Dementia Sub-Study)
• •5. Have the ability to complete a mini-mental status evaluation
• •6. Have the ability to independently comprehend and complete a quality of life and dementia questionnaires.
• •7. Ability to provide informed consent for study participation
• •8. Willing and able to comply with the prescribed follow-up tests and schedule of evaluations.
• •5. Participation in any other clinical trials involving an investigational or marketed drug within 30 days prior to entry in this study;
• •6. Other conditions that in the opinion of the Principal Investigator may increase risk to the subject and/or compromise the quality of the clinical trial