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COMPLETEDNANCT03077139

Cardiac Resynchronization Therapy in Pulmonary Hypertension

This study is being conducted to determine whether patients with advanced pulmonary hypertension when treated with cardiac resynchronization therapy improve hemodynamically and/or receive clinical ben...

Lead sponsor: Dr. Daniel P Morin, MD MPH FHRS•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Dr. Daniel P Morin, MD MPH FHRS

This study aims to determine whether stimulating earlier activation of the failing right ventricle in pulmonary hypertension reduces the effects of interventricular dependence in human subjects, thereby improving overall cardiac function and symptoms in patients with pulmonary hypertension and right ventricle failure with NYHA Class 3-4 symptoms.

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Pulmonary hypertension, defined as pulmonary artery systolic pressure greater than 40 mm Hg by transthoracic echocardiogram or right heart catheterization
•LVEF ≥ 50%
•Baseline 6MWT distant \<400 meters
•Baseline NYHA Functional class ≥ III

Exclusion Criteria

•LVEF \< 50%
•6MWT duration \> 400 meters
•NYHA Functional class \< III
•Left bundle branch block
•Non-sinus rhythm
•Severe aortic stenosis (Aortic valve area \< 1 cm2)
•Severe mitral regurgitation
•Acute cardiac failure
•Dependency on intravenous inotropies
•Severe obstructive pulmonary disease
•Hypertrophic obstructive cardiomyopathy
•Amyloidosis
•Dependence on pacing

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: September 20, 2017Terms

Trial snapshot

StatusCOMPLETED

PhaseNA

Enrollment6

Start dateNov 2012

Last updatedSep 20, 2017

Condition

Pulmonary Hypertension

Locations shown

Ochsner Medical Center

New Orleans, Louisiana

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 20, 2017Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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