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Carvedilol, Endoscopic Variceal Ligation or Combination of Both for Prevention of First Variceal Bleed in Child's B & C Cirrhosis | Clinical Trials | Clareo Health

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Carvedilol, Endoscopic Variceal Ligation or Combination of Both for Prevention of First Variceal Bleed in Child's B & C Cirrhosis

Carvedilol, Endoscopic Variceal Ligation or Combination of Both for Prevention of First Variceal Bleed in Child's B & C Cirrhosis: A Randomized Controlled Trial

NCT03069339•Institute of Liver and Biliary Sciences, India

View on ClinicalTrials.gov

Summary

Study Design: Open labeled randomized controlled trial. The study will be conducted on patients attending outpatient or admitted to admitted to Department of Hepatology from January 2017 to December 2018 at ILBS, New Delhi

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Liver Cirrhotics between 18-70 yrs of age (cirrhosis diagnosed on the basis of clinical, biochemical, fibroscan \& imaging.)
•CTP ≥ 7-15 (Child's B/C)
•Small esophageal varices with RCS and large esophageal varices (\>5 mm)
•No history of previous bleed

Exclusion Criteria

•Malignancy-HCC, PVT
•Child A
•MELD \>35
•Contraindications to β blockers.
•Platelet count \< 30,000/mm3
•Previous endoscopic variceal treatment. (Beyond 21 days)
•Patients having an indication for TIPS or requiring more than 1 therapeutic ascitic tapping/month
•Post TIPS, Shunt surgery
•Acute kidney injury (Sr.Cr\>1.5mg/dl)
•Non cirrhotic portal hypertension
+1 more criteria

Locations (1)

Institute of liver and Biliary Sciences

New Delhi, National Capital Territory of Delhi, India

Key Dates

Start Date

March 15, 2017

Primary Completion Date

November 30, 2020

Completion Date

November 30, 2020

Last Updated

February 19, 2020

Enrollment

330

ACTUAL participants

Conditions

Cirrhosis

Interventions

Carvedilol

DRUG

Endoscopic Variceal Ligation

PROCEDURE

EUS Guided Portal-systemic Pressure Gradient Measurement to Predict Treatment Response and Outcomes of Varices to Endoscopic Variceal Ligation in Patients With Chronic Hepatitis.

NCT05597488

Cirrhosis Portal

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RECRUITINGNA

Remote Electrical Stimulation for Pain and Depression Treatment in Cirrhosis

NCT06932783

Cirrhosis

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RECRUITING

Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 19, 2020Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Carvedilol, Endoscopic Variceal Ligation or Combination of Both for Prevention of First Variceal Bleed in Child's B & C Cirrhosis

Inclusion Criteria

Exclusion Criteria

EUS Guided Portal-systemic Pressure Gradient Measurement to Predict Treatment Response and Outcomes of Varices to Endoscopic Variceal Ligation in Patients With Chronic Hepatitis.

Remote Electrical Stimulation for Pain and Depression Treatment in Cirrhosis

Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias

Mechanism of TIPS to Improve Sarcopenia

Diagnosis of Lymphohistiocytic Hemophagocytosis in Intensive Care

Verification of Risk Factors of Thrombohemorrhagic Complications in Recipients After Related Liver Transplantation