Loading clinical trials...

Remote Electrical Stimulation for Pain and Depression Treatment in Cirrhosis | Clinical Trials | Clareo Health

RECRUITINGNA

Remote Electrical Stimulation for Pain and Depression Treatment in Cirrhosis

RESTORE: Remote Electrical Stimulation for Pain and Depression Treatment in Cirrhosis

NCT06932783•University of Michigan

Summary

This study is being done to better understand how the study team can treat pain for people with cirrhosis and depression. Enrolled participants on this feasibility study will be randomized to Transcutaneous Electrical Acustimulation (TEA) or sham TEA.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Diagnosis of cirrhosis - must meet the criteria as outlined in the protocol
•Chronic pain (Patient self-reports ≥ 4 on the 0-10 scale for \>50% of days within 3- months)
•Depression (in at least half of participants) - must meet the criteria as outlined in the protocol
•English speaking
•Willing to use a Transcutaneous Electrical Acustimulation device

Exclusion Criteria

•Dementia and/or severe cognitive impairment
•Unable or unwilling to provide consent
•Expected to undergo liver transplant in next 24 weeks
•No email address
•Deemed unsuitable by the study investigator

Locations (1)

University of Michigan

Ann Arbor, Michigan, United States

Key Dates

Start Date

July 22, 2025

Primary Completion Date

July 1, 2027

Completion Date

July 1, 2027

Last Updated

March 6, 2026

Enrollment

ESTIMATED participants

Conditions

Cirrhosis

Interventions

Transcutaneous Electrical Acustimulation (TEA)

DEVICE

Sham Transcutaneous Electrical Acustimulation (TEA)

DEVICE

Contacts

Tasnuva Tarannum

CONTACT

734-232-4182 tasnuvat@med.umich.edu

Samantha Nikirk

CONTACT

734-232-4182 samjwalk@med.umich.edu

EUS Guided Portal-systemic Pressure Gradient Measurement to Predict Treatment Response and Outcomes of Varices to Endoscopic Variceal Ligation in Patients With Chronic Hepatitis.

NCT05597488

Cirrhosis Portal

View study

RECRUITING

Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias

NCT06306963

Gastric Antral Vascular EctasiaCirrhosis+1 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 6, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Remote Electrical Stimulation for Pain and Depression Treatment in Cirrhosis

Inclusion Criteria

Exclusion Criteria

EUS Guided Portal-systemic Pressure Gradient Measurement to Predict Treatment Response and Outcomes of Varices to Endoscopic Variceal Ligation in Patients With Chronic Hepatitis.

Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias

Mechanism of TIPS to Improve Sarcopenia

Diagnosis of Lymphohistiocytic Hemophagocytosis in Intensive Care

Verification of Risk Factors of Thrombohemorrhagic Complications in Recipients After Related Liver Transplantation

Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure