Efficacy and Safety of S-amlodipine 2,5 mg and 5 mg in Hypertension Patients

Exclusion Criteria

• •Pregnant patients, nursing mothers or female patients who have potential for childbearing and do not use any effective contraceptive method.
• •Allergy or hypersensitivity to dihydropyridines.
• •Patients receive more than one anti-hypertensive medicine.
• •Patients with seconder hypertension.
• •Patients with severe hypertension, myocardial infarction, NYHA stage 2-4 cardiac insufficiency, history of cerebrovascular disease, past ischemic attack, encephalopathy, underwent coronary artery bypass surgery or percutaneous coronary intervention, second or third degree heart block or symptomatic arrhythmia without pacemaker, clinically significant heart valve disease, potential life-threatening or symptomatic arrhythmia, simultaneous unstable angina pectoris, type I diabetes mellitus, atrial fibrillation until the last 12 months.
• •Uncontrolled type II diabetes mellitus.
• •Patients with significant liver disease (ALT, AST must be \> 2XULN in beginning, patients with esophageal varices, portacaval shunt).
• •Patients with significant kidney disease (GFR \<60 ml/min according to Cockcroft-Gault formula).
• •Patients with volume depletion.
• •Patients with pancreas disease.
• •Patients with gastrointestinal disease which may effect absorption.
• •Drug/narcotic and alcohol abuse until the last 12 months.
• •Patients with central nervous system disease and taking medicine for this reason.
• •History of incompatibility with medical regimes or patients do not want to adhere the study protocol.
• •Persons directly involved in the management of this protocol.