Transcranial Magnetic Stimulation (TMS) in Obesity

Exclusion Criteria

• •1. Axis-I and II psychiatric disorders according to DSM criteria 5 (such as Major Depression, Bipolar Disorder, or Attention Deficit Disorder)
• •2. IQ score \< 85
• •3. Organic brain disorders: history of stroke, brain major surgery or head trauma
• •4. Pregnancy or lactation, absence of medically approved contraceptive methods in females of childbearing potential
• •5. Serious or poorly controlled diseases (hepatic, renal or hearth failure, atrial fibrillation or other heart rhythm disorders)
• •6. H yperglycemia - Fasting glucose level \> 170 mg/dl
• •7. Urine drug screen positive for amphetamines, barbiturates, cannabinoids, cocaine metabolites, opiates and phencyclidine
• •8. Positivity to blood alcohol test
• •9. Metal in any part of the head, except for dental fillings
• •10. Implanted infusion pumps
• •11. Intracardiac devices (pacemakers, heart valves ...)
• •12. History of diseases whose exacerbation could be fatal (e.g. cardiovascular disease, increased intracranial pressure)
• •13. History of epilepsy or a family history of epilepsy among first-degree relatives
• •14. Medications associated with lowered seizure threshold (such as antidepressants, anxiolytics…)
• •15. Treatment with anti-obesity medications or other medications influencing body weight within 3 month prior to Screening Visit
• •16. Starting a weight loss plan at any time during data collection for the subject
• •17. Patients affected by galactosemia, priapism and terminal illness
• •18. Patients on fluid restriction for SIADH or other conditions
• •19. Contraindications to perform the Magnetic Resonance Imaging (MRI).