Collagenase Injection vs Percutaneous Needle Aponeurotomy for Dupuytren's Disease

Exclusion Criteria

• •Patients who have had previous interventions of contracture presenting for treatment, in an effort to compare similar disease state and risk with each procedure.
• •Disease involving DIP joint or thumb, as collagenase has not been approved for use in the thumb or DIP joints.
• •Pregnant or nursing, although there is data indicating no detection of collagenase in patient serum following injection for Dupuytren's contractures, there is no data exploring the effects of collagenase on a fetus or infant.
• •Anticoagulation therapy other than ASA (held 7 days prior to procedure), which is a recommendation by the manufacture of collagenase used in this study.