Investigating the Use of Genetics to Guide Pharmacologic Therapy for Hypertension

Specific Aim: To determine the efficacy of genetically guided therapeutic options for pharmacologic treatment of essential hypertension, when compared to conventional standard of care (JNC 8 guideline directed therapy). Hypothesis A: Patients randomized to genetically guided blood pressure therapy will have significantly reduced time to optimal blood pressure control compared to conventional standard of care. Hypotheses B: Patients randomized to genetically guided blood pressure therapy will have significantly greater absolute blood pressure reduction compared to conventional standard of care. Hypothesis C: Patients randomized to genetically guided blood pressure therapy will have to take fewer classes of blood pressure medicines in order to achieve blood pressure control. Secondary Aim: To determine if genetically guided blood pressure therapy reduces number of medication changes in patients with hypertension. Hypotheses: Patients randomized to genetically guided blood pressure therapy will have significantly less medication changes.