Facilitating the Behavioral Treatment of Cannabis Use Disorder

Exclusion Criteria

• •Meets DSM IV criteria for current major depression, bipolar disorder, schizophrenia, any psychotic illness, including substance-induced psychosis, and current substance-induced mood disorder.
• •Physiological dependence on another substance requiring medical management, such as alcohol, opioids, or benzodiazepines, excluding caffeine, and nicotine.
• •Pregnant, interested in becoming pregnant, or lactating
• •Delirium, Dementia, Amnesia, Cognitive Disorders, or dissociative disorders
• •Current suicide risk or a history of suicide attempt within the past 2 years
• •On psychotropic or other medication whose effect could be disrupted by participation in the study
• •Recent history of significant violence (past 2 years).
• •Heart disease as indicated by history, abnormal ECG, previous cardiac surgery.
• •Unstable physical disorders which might make participation hazardous such as end-stage AIDS, hypertension (\>140/90), anemia, pulmonary disease, active hepatitis or other liver disease (transaminase levels \< 2-3 X the upper limit of normal will be considered acceptable), or untreated diabetes
• •Previous history of misuse of study medications
• •BMI \> 35, or a history of undocumented obstructive sleep apnea
• •First degree relative with a psychotic disorder (bipolar disorder with psychotic features, schizophrenia, schizoaffective disorder, or psychosis NOS)