The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy

Exclusion Criteria

• •History of medical events such as surgical interventions or neurologic conditions (e.g., multiple sclerosis), trauma, or infections that are associated with the development of symptoms of premature ejaculation (PE) and considered a potential cause of PE,
• •Having genital abnormalities, except penile curvature unless not prevent sexual intercourse,
• •Developed ED or PE due to drug use or quit taking drugs,
• •Any conditions that prevent sexual intercourse with partners
• •History of epilepsy,
• •Severe renal insufficiency,
• •Liver disease,
• •History of in last 6 months stroke, myocard infarction, cardiac insufficiency (New York Cardiovascular Associates (NYCA) phase II-IV), AV block or message disorder such as sick sinus syndrome, severe ischemic cardiac disease, syncope, unstable angına, life-threatening arrhythmia or hypotension,
• •Non-Arteritic Anterior ischemic optic neuropathy,
• •Autonomic neuropathy, retinitis pigmentosa, blood diseases, active peptic ulcer, abnormalities in ECG, severe systemic disease that cannot be controlled,
• •Systolic/Diastolic blood pressure at rest \<90/50mmHg and 170/100mmHg\<
• •History of allergy to Selective Serotonine Reuptake Inhibitor (SSRI) and phosphodiesterase inhibitor drugs,
• •Continuing to use or quitted in last 3 months of Monoamine oxidase inhibitor (MAOI), Thioridazine, Serotonine Reuptake Inhibitor (SSRI), Selective-Norepinephrin Reuptake Inhibitor (SNRI), Serotonergic drug/herbal product, tricyclic antidepressant and atypical antipsychotic drugs,
• •Use of nitrates, alfa blockers, vasodilators, ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone, nelfinavir, atazanavir, cimetidine, erithromicin, clarithromycin, fluconazole, amprenavir, fosamprenavir, aprepitant, verapamil, diltiazem, any kind of vasodilator, antiplatelet, anticoagulant, dapoxetine, PDE5 inhibitor, alcohol and stimulant drug,
• •Patients on a different therapy (behavioral therapy or other drugs that are applied locally) for PE treatment
• •During the study, the possibility of taking medication which may affect the study drug's pharmacokinetic/pharmacodynamic properties
• •Patients who are defining symptoms of prostatitis clinically
• •Thyroid hormone disorders