Lead Sponsor

University of North Carolina, Chapel Hill

Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Age

18 - 45 years

Sex

FEMALE

Healthy Volunteers

No

•Maternal age 18-45 years
•Singleton pregnancy with no known fetal anomalies
•Gestational age between 10weeks 0 days and 22 weeks 6 days by menstrual dating confirmed by ultrasound, or ultrasound alone
•Clinical diagnosis of preexisting T2DM requiring medical treatment (oral agent or insulin)
•Clinical diagnosis of diabetes diagnosed between 10 weeks and \< 20 weeks 6 days gestation
•Willing to start insulin therapy and discontinue oral hypoglycemic pills other than study pills
•Able to swallow pills

•Clinical diagnosis of pre-existing renal disease, defined as creatinine \> 1.5 mg/dL
•Clinical history of lactic acidosis
•Known allergy to metformin
•Participation in another study that could affect primary outcome
•Delivery planned at non-MOMPOD study locations
•Unwillingness to use insulin treatment or follow prenatal care doctor's instructions for insulin and blood glucose monitoring