Study of Pegilodecakin (LY3500518) With FOLFOX Compared to FOLFOX Alone Second-line Tx in Participants With Metastatic Pancreatic Cancer

Exclusion Criteria

• •8. No peripheral neuropathy
• •9. No known history of dihydropyrimidine dehydrogenase deficiency
• •1. Diagnosis of pancreatic islet neoplasm, acinar cell carcinoma, non- adenocarcinoma (i.e., lymphoma, sarcoma), adenocarcinoma originating from the biliary tree, or cystadenocarcinoma
• •2. Participant on Coumadin and not willing to change to LMWH or oral Factor II or Xa inhibitor with half-life of less than 24 hours.
• •3. Participant has received prior treatment with pegilodecakin or fluoropyrimidine/platinum containing regimen
• •4. Participants who were intolerant of a gemcitabine containing regimen.
• •5. History of positivity for human immunodeficiency virus
• •6. Chronic active or active viral hepatitis A, B, or C infection
• •7. Clinically significant bleeding within two weeks prior to randomization (e.g., gastrointestinal (GI) bleeding, intracranial hemorrhage)
• •8. Pregnant or lactating women
• •9. Participants with a history of immune-mediated neurological disorders such as multiple sclerosis, Guillain-Barré or inflammatory CNS/PNS disorders
• •10. Clinically significant ascites defined as requiring ≥ 1 paracentesis every 2- weeks
• •11. Major surgery, defined as any surgical procedure that involves general anesthesia and a significant incision (i.e., larger than what is required for placement of central venous access, percutaneous feeding tube, or biopsy),within 28 days prior to randomization or anticipated surgery during the study period
• •12. Prior history of receiving immune modulators including, but not limited to, anti-CTLA4, anti-PD1, anti-PD-L1