Penicillin for the Emergency Department Outpatient Treatment of CELLulitis

Exclusion Criteria

• •Penicillin allergy (self-reported or confirmed).
• •Any cellulitis, wound infection and abscess that treating clinicians deem treatable with intravenous (IV) antibiotics.
• •Any cellulitis, wound infection and abscess that is more severe than Eron Class 2 (Appendix 2)
• •Any cellulitis, wound infection and abscess of the perineal region.
• •Patients who have received more than 24 hours of effective antibiotics for the current episode of acute cellulitis, wound infection or abscess
• •Any medical condition, based on clinical judgment, that may interfere with interpretation of the primary outcome measures (e.g. chronic skin condition at the lesion site)
• •Immunodeficiency from primary or secondary causes (e.g. corticosteroids, chemotherapeutic agents).
• •Previous history of renal dysfunction or known chronic kidney disease under care of a nephrologist. - Previous history of liver dysfunction defined as chronically deranged liver function tests elicited from medical notes or history.
• •Suspected or confirmed septic arthritis.
• •Suspected or confirmed osteomyelitis.
• •Infection involving prosthetic material.
• •Pregnant or lactating women.
• •Patients with a previous history of flucloxacillin- associated jaundice/hepatic dysfunction
• •Patients with a previous history of MRSA colonization/infection.
• •Patients with lactose intolerance diagnosed by a medical professional