Clinical Trial of CT1812 in Mild to Moderate Alzheimer's Disease

Inclusion Criteria

• •1. Willing and able to provide written informed consent prior to initiation of any study-related procedures. For subjects unable to provide written consent, consent will be provided by the Person Responsible per local regulations.
• •2. Men and women, 50-80 years in age inclusively with a diagnosis of mild to moderate Alzheimer's disease according to the 2011 NIA-AA. Women must be neither pregnant nor nursing, and are either surgically sterile, postmenopausal or premenopausal using an acceptable method of contraception.
• •3. Previous decline in cognition for more than six months.
• •4. Neuroimaging (MRI) obtained within the previous 6 months or during screening, consistent with the clinical diagnosis of Alzheimer's disease.
• •5. MMSE 18-26 inclusive.
• •6. No active depression and a Geriatric Depression Score (GDS) of \< 6.
• •7. Modified Hachinski Ischemia score ≤ 4.
• •8. Formal education of eight or more years.
• •9. Living at home or in a community setting (assisted living) without continuous nursing care. Each subject must have a reliable caregiver who sees them at least 3 times weekly, can oversee the administration of study drug, and is willing and able to participate in all clinic visits and some study procedures. Responsible caregiver must provide written informed consent to participate.
• •10. Concurrent use of acetylcholinesterase inhibitors or memantine must be stable for 90 days prior to screening and not expected to change.