Evaluation of the Safety and Potential Therapeutic Effects of CB-AC-02 in Patients With Alzheimer's Disease

Exclusion Criteria

• •1. Concurrent Dementia as a result of other disorders \[i.e. infectious disease of the central nervous system such as HIV, syphilis, head injury, Creutzfeld-Jacob disease, Picks disease, Huntington's disease, Parkinson's disease, other subdural hematoma, hydrocephalus and structural brain lesions, drug addiction, alcoholism, substance abuse, thyroid disease, parathyroid disease, vitamins and other nutritional deficiencies and vascular etc.\]
• •2. Subject with vascular dementia as determined by the clinical criteria of DSM-IV and the imaging criteria of Erkinkuntii
• •3. Subject with severe white matter hyperintensities (i.e. ≥ 25mm of the deep white matter and ≥ 10mm of the periventricular capping/banding in lengths)
• •4. Abnormal laboratory findings at screening visit
• •5. Subjects who are positive for HIV, syphilis or active HBV, HCV infection
• •6. Subjects in poor medical condition or subjects with severe cardiovascular, gastrointestinal, pulmonary or endocrinologic disease A. Suspected active active lung disease on chest X-ray at screening visit B. Diagnosis of cancer (except for the subjects who remains in complete remission for 5 years or more )
• •7. Subject with concurrent unstable psychiatric disorder (i.e. severe depression, or schizophrenia, or bipolar disorder, etc)
• •8. Pregnant or lactating women
• •9. Women of childbearing age who reject to practice contraception with one of the following methods
• •* Use a condom
• •* Use of contraceptive (oral, dermal, or injectable)
• •* Use an intra-uterine contraceptive device
• •10. Subjects with a history of alcohol abuse (\>30g/day) or drug abuse
• •11. Subjects who cannot undergo any of the tests performed in this clinical trial (for example, MRI, CT, PET, CSF study)
• •12. Subjects with known allergies to protein products (Bovine serum), antibiotics (gentamycin) or DMSO
• •13. Subjects whom the principal investigator considers inappropriate for participation in theis study