Plasma Exchange Combination of Immunosuppressive Regimens for Auto-immune Hepatitis

Exclusion Criteria

• •The presence of hepatitis A, B, C, D, or E virus infection;
• •* Patients with presence of liver cirrhosis or portal hypertension;
• •* Primary sclerosing cholangitis, non-alcoholic steatohepatitis, drug induced liver disease or Wilson disease confirmed by liver biopsy;
• •* Pregnant and breeding women;
• •* Patients with severe anemia (hemoglobin \< 8 g/dL), leukopenia (WBC \< 2500/mm3), or thrombocytopenia (platelet count \< 50,000/mm3);
• •* Severe disorders of other vital organs, such as severe heart failure, cancer;
• •* Parenteral administration of blood or blood products within 6 months before screening;
• •* Recent treatment with drugs having known liver toxicity;
• •* Taken part in other clinic trials within 6 months before screening.