Mycophenolate Mofetil Versus Cyclosporin A in the Treatment of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome Due to Nonresponse to Standard Therapy

Exclusion Criteria

• •1. The presence of hepatitis A, B, C, D, or E virus infection;
• •2. Patients with presence of serious decompensated cirrhosis;
• •3. Patients have a history of glucocorticoid or immunosuppressant medication before enrollment;
• •4. Liver damage caused by other reasons: such as primary sclerosing cholangitis, non-alcoholic steatohepatitis, drug induced liver disease or Wilson's disease.
• •5. Pregnant and breeding women and women of childbearing age in need of reproduction
• •6. Severe disorders of other vital organs, such as severe heart failure, cancer;
• •7. Patients with presence of renal insufficiency;
• •8. Parenteral administration of blood or blood products within 6 months before screening;
• •9. Recent treatment with drugs having known liver toxicity;
• •10. Taken part in other clinic trials within 6 months before enrollment.
• •11. Patients who are allergic to these drugs;
• •12. Uncontrolled infection and hypertension ;