Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation

Inclusion Criteria

• •Male or female age 15 to 24
• •Meet DSM-5 criteria for a substance use disorder
• •Substance use ≥ 14 days of past 28 days (i.e. use ≥ 50% of days in the past 28 days)
• •If subject in restricted setting/care (e.g. inpatient detox unit or residential treatment) for ≤ 2 weeks, then use ≥ 50% of days while outside of restricted setting (e.g. 7 days of substance use out of 14 days in unrestricted setting)
• •Subjects need to have been in an unrestricted setting for at least 2 weeks prior to screening
• •Meets DSM-5 criteria for bipolar disorder or disruptive mood dysregulation disorder or DSM IV criteria for mood disorder not otherwise specified
• •Symptoms of SMD: Youth Self Report (YSR) or Adult Self Report (ASR) AAA ≥180
• •Stable to be treated in outpatient level of care