Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disorder Comorbid With Obesity

Exclusion Criteria

• •221/5000
• •1. Individuals with other DSM-5 spectrum disorders;
• •2. Mental disorders caused by substance abuse (such as alcohol, drugs, etc.), and those with severe physical illnesses;
• •3. Those who consumed food or microecological preparations containing probiotics, prebiotics, etc. within one week before enrollment, and had a history of respiratory, urinary, digestive system infections and antibiotic use within one month before enrollment;
• •4. Those currently having serious suicidal thoughts or behaviors, or those with severe agitation;
• •5. Those who cannot follow medical advice for treatment, or those without guardians;
• •6. Pregnant or lactating women, or those planning to become pregnant;
• •7. Those who cannot complete MRI examinations due to special conditions such as having metal implants or pacemakers in their bodies.