Safety of Anti-Depressant for Chronic Obstructive Pulmonary Disease (SAD-COPD)

Exclusion Criteria

• •Current treatment with antidepressants
• •Current treatment with anti-psychotics
• •Severe physical disability that would interfere with lung assessment
• •History of major psychiatric illness, including bipolar disorder, psychoses, and/or severe personality disorder.
• •Active suicidal ideations
• •Serious cognitive problems (dementia syndrome) or cognitive impairment defined as MMSE \< 22
• •Recent loss of spouse within 6 weeks of study enrollment.
• •History of alcohol or drug dependence in the last 6 months.
• •Pregnant women or nursing mothers
• •Poorly controlled concomitant conditions that pose additional procedure risk as determined by the investigator.