The Impact of Reward-induced Dopamine Release on Functional Connectivity: a Combined PET/fMRI Study

Exclusion Criteria

• •1. Left-handed or ambidextrous
• •2. History of seizures
• •3. History of strokes
• •4. Clinically significant, uncontrolled liver, kidney, cardiac, or pulmonary disease
• •5. Terminal medical diagnosis consistent with survival \< 1 year
• •6. Serious mental impairment. Mini mental state exam of \< 23/30
• •7. Current or past DSM-IV Axis I or neurologic disorders
• •8. Actively abusing substances, including alcohol (regular alcohol use during the past 6 months equal to or greater than 16 cans of beer per week or equivalent; use of street drugs or regular tobacco use during the past 6 months)
• •9. Unstable medical condition (≥ 3 months), or serious medical illnesses during the past three months (e.g., serious infections)
• •10. Unexplained loss of consciousness; history of traumatic brain injury involving loss of consciousness greater than 2 minutes
• •11. Currently pregnant or breastfeeding, sexually active and of child-bearing potential and not using adequate contraceptive methods
• •12. Childbirth or miscarriage during past 6 months, breastfeeding within 6 months of recruitment
• •13. Allergic to latex and/or study pharmaceuticals
• •14. Diabetes and/or unable to fast for up to 7 hours
• •15. Unable to lie comfortably in the scanner for up to 4 consecutive hours
• •16. Would receive a total of over 5 rems to a radiosensitive organ (bone marrow, gonads, lens of the eye) or 15 rems to any other organ or to the body as a whole during a 12 month period
• •17. Contraindications for MRI including neurostimulators, implanted medical devices, metal in the body, claustrophobia, weight over 440 pounds, and girth size incompatible for scanner bore.
• •18. Participation in a similar Social Feedback Task within 2 months of the start of the study.