Safety and Immunogenicity of Recombinant Hepatitis B Vaccines in the Neonates

Exclusion Criteria

• •Family history of eclampsia, epilepsy and encephalopathy;
• •Subjects' birth mother had immune system dysfunction, or history of organ transplantation or blood dialysis;
• •Subjects' parents had a medical history of allergic to any ingredient of the vaccine, including supplementary material and formaldehyde;
• •Subjects' parents had a medical history of allergic to combined hepatitis A and B vaccine(HAB) or hepatitis B vaccine;
• •Subjects had serious acute and chronic diseases;
• •with temperature ≧37.1℃;
• •Any condition that in the opinion of the investigator, may interfere with the evaluation of study objectives.