First in Patient Study for PF-06840003 in Malignant Gliomas

Inclusion Criteria

• •Diagnosis of WHO Grade IV glioblastoma or WHO Grade III anaplastic gliomas
• •For patients with Grade IV GBM, recurrent disease at the time of the first or second recurrence or progression. For patients with Grade III anaplastic gliomas, recurrent disease at the time of at least a first recurrence but no more than a fourth recurrence or progression
• •Karnofsky performance score greater than or equal to 70%
• •Adequate bone marrow, kidney and liver function