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Computerized Working Memory Training in Children With ADHD and Comorbid Tourette Syndrome | Clinical Trials | Clareo Health

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Computerized Working Memory Training in Children With ADHD and Comorbid Tourette Syndrome

Computerized Working Memory Training in Children With Attention-Deficit/Hyperactivity Disorder and Comorbid Tourette Syndrome

NCT02732496•Massachusetts General Hospital

View on ClinicalTrials.gov

Summary

The investigators will conduct a randomized placebo-controlled trial of a computerized intervention targeting working memory in 30 children with comorbid Attention-Deficit/Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS).

Detailed Description

Because impairments in executive functions (EFs), such as working memory, are associated with functional impairments in youth with neurodevelopmental and neuropsychiatric disorders, strategies that target EFs are critical. Neuroplasticity-based cognitive training has been found to improve cognition in youth with ADHD and in adults with schizophrenia. In this trial, the investigators seek to extend the relevance of computerized cognitive training to youth with comorbid ADHD and Tourette Syndrome. Given the literature, the investigators hypothesize that computerized working memory training will produce gains in untrained cognitive tasks and behavioral ratings of executive functions in youth with ADHD+TS. The investigators will assess aspects of attention and executive functions in 30 affected youth and randomize them 1:1 to either neuroplasticity-based cognitive training or enjoyable age-appropriate computer games not intended to improve cognition. Cognition will be assessed again after 30 training sessions over 6 weeks and then again at a one-month follow-up.

Eligibility

Age

7 - 13 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. The investigators will limit inclusion to youth between the ages of 7-13 who carry current diagnoses of ADHD+TS and who have a treating physician at a Partners affiliated hospital or clinic.
•2. The investigators will include youth who have undergone neuropsychological testing in the prior 3 years.

Exclusion Criteria

•1. The investigators will exclude patients with intellectual disability in order to more directly extend the prior literature to the ADHD+TS population.
•2. The investigators will exclude patients with severe tics as evidenced by a score of \> 30 on the clinician administered Yale Global Tic Severity Scale (YGTSS).
•3. The investigators will exclude patients with moderate to severe Obsessive Compulsive Disorder (OCD) symptoms, as evidenced by a score of \>30 on the clinician administered Children's Yale-Brown Obsessive Compulsive Scale (CYBOCS).
•4. The investigators will exclude patients treated with neuroleptics, given that these medications can be cognitively dulling and sedating and potentially lead to secondary working memory impairments.
•5. The investigators will exclude families who do not have a computer with an internet connection in their homes, and in which neither a parent nor the child has an email address to receive study related communications.
•6. The investigators will exclude families who anticipate or are likely to have a change in therapeutic treatments (i.e., psychotherapy or psychopharmacology) during the time frame of the trial.
•NOTE: Patients treated with ADHD medications will not be excluded, but medications will be recorded for covariate analysis.

Key Dates

Start Date

June 1, 2016

Primary Completion Date

November 3, 2017

Completion Date

November 3, 2017

Last Updated

August 3, 2018

Enrollment

ACTUAL participants

Conditions

Attention-Deficit/Hyperactivity DisorderTourette Syndrome

Interventions

Targeted Cognitive Training (TCT)

BEHAVIORAL

Youth Appropriate Online Games

OTHER

CBIT+TMS R33 Phase

NCT06678737

TicsTourette Syndrome

View study

RECRUITING

Sensory Symptoms in Tourette Syndrome

NCT03851484

Tourette Syndrome

View study

RECRUITING

Observational Database on Deep Brain Stimulation in Tourette Syndrome

NCT04449068

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 3, 2018Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Computerized Working Memory Training in Children With ADHD and Comorbid Tourette Syndrome

Inclusion Criteria

Exclusion Criteria

CBIT+TMS R33 Phase

Sensory Symptoms in Tourette Syndrome

Observational Database on Deep Brain Stimulation in Tourette Syndrome

Neurofeedback From the Supplementary Motor Area for Tourette Syndrome

Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics

Cognitive-psychophysiological Treatment for Tics in Young People With Tourette's Syndrome With or Without Biofeedback