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Epigenetic Regulation of Human Adipose Tissue Distribution | Clinical Trials | Clareo Health

ACTIVE_NOT_RECRUITINGNA

Epigenetic Regulation of Human Adipose Tissue Distribution

NCT02728635•AdventHealth Translational Research Institute

Summary

The purpose of this study is to collect data to help researchers better understand the different ways that women or men store fat (apple shape versus pear shape).

Eligibility

Age

18 - 45 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Age 18-45 years inclusive;
•BMI 23-35 kg/m2 inclusive;
•HbA1C \<6.0%;
•Weight stable (± 3 kg) during the 3 months prior to enrollment;
•Women must be \> 9 months post-partum;
•Able to provide written, informed consent.

Exclusion Criteria

•Postmenopausal women
•Women with an oophorectomy
•Fasting plasma glucose \> 126 mg/dL, or diagnosis with Type 2 Diabetes (T2DM)
•Untreated or symptomatic thyroid disease.
•Aminotransferase or aspartate aminotransferase \> 3x upper limit of laboratory reference range, or known diagnosis of liver disease.
•Creatinine \> 2x upper limit of laboratory reference range, or known diagnosis of kidney disease.
•Uncontrolled hypertension (BP \> 140 systolic or \> 90 diastolic)
•New onset (\<3 months on a stable regime) use of oral contraceptives or hormone replacement therapy.
•History of drug or alcohol abuse (\> 3 drinks per day) within the last 5 years, or psychiatric disease prohibiting adherence to study protocol. Current drug use may be determine by plasma or urine drug screens.
•History of cancer within the last 5 years (skin cancers, with the exception of melanoma, may be acceptable).
+11 more criteria

Locations (1)

Translational Research Institute for Metabolism and Diabetes

Orlando, Florida, United States

Key Dates

Start Date

July 1, 2016

Primary Completion Date

July 11, 2018

Completion Date

December 1, 2025

Last Updated

March 13, 2025

Enrollment

ACTUAL participants

Conditions

Obesity

Interventions

Dual-energy X-ray absorptiometry (DEXA)/ Magnetic resonance imaging (MRI) and Magnetic resonance spectroscopy (MRS)

OTHER

Adipose tissue biopsies

PROCEDURE

FSIGTT/ RMR

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 13, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Epigenetic Regulation of Human Adipose Tissue Distribution

Inclusion Criteria

Exclusion Criteria

Multi-Acupoint Laser Therapy for Body Shape and Composition in Obese Menopausal Women

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