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Proof of Concepts: Can a Supplement Ketogenic Based MCT Oil Increases Cerebral Capture Ketones in People With Alzheimer's Disease?
Evaluate and compare the changes in brain ketone and glucose uptake after taking two different MCT oil emulsions (60-40 oil or C8 oil) for one month, in a group of people with Alzheimer's disease and a control group.
Based on a PET/MRI protocol, the aim of this study is to evaluate and compare the response to the dietary supplementation of two different MCT oils (60% C10 + 40% C8 or 100 % C8) in two groups, patients with Alzheimer's disease and healthy elderly people (N=10/group). After a baseline evaluation, participant will test one of the supplements during two successive periods of one month; each period of time ending with 18F-FDG and 11C-acetoacetate PET scans.
Age
65 - No limit years
Sex
ALL
Healthy Volunteers
Yes
Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)
Sherbrooke, Quebec, Canada
Start Date
October 1, 2015
Primary Completion Date
February 1, 2018
Completion Date
February 1, 2018
Last Updated
October 10, 2018
20
ACTUAL participants
1-month of 60-40 MCT oil
DIETARY_SUPPLEMENT
1-month of C8 MCT oil
DIETARY_SUPPLEMENT
Lead Sponsor
Université de Sherbrooke
Collaborators
Data Source & Attribution
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View ClinicalTrials.gov Terms and ConditionsNCT07033494