Unloading Induced Effects on Local Glucose Uptake Into m. Soleus

Exclusion Criteria

• •Smoker
• •Competitive Athletes
• •Diabetes mellitus
• •Rheumatic disease
• •Muscle or joint disease
• •Bone fractures in the period up to one year before study start
• •Herniated disc
• •Flatfeet (pes planus)
• •Allergy to nuts or legume
• •Vascular diseases
• •Epilepsy
• •Severe hyperlipidemia
• •Anemia (\< Hb standard values; standard values healthy men: 13.5 -17.5 g/dl) \*
• •Increased thrombosis risk \*
• •Kidney disorder: deviations from normal values for creatinine in plasma. (Normal value: Creatinine \< 1.20 mg/dl)\*
• •Lesions of the cruciate ligaments, or orthopedic surgery in the past 10 years on the side of the Hephaistos orthosis
• •Achilles tendon injury, or rupture in the past 10 years on the side of the orthosis
• •hyper-/hypocalcaemia (abnormal levels of calcium in the blood, normal level: 2.15 - 2.64 mmol/l)
• •Intake of anti-inflammatory drugs during the study
• •Abuse of drugs or alcohol (\> than 20-30g alcohol/day)
• •Participation in another clinical study within the last 2 months before the start of this study
• •Increased bleeding tendency (hemophilia, regular use of anticoagulants)
• •History of intolerance to local anesthetics
• •Imprisoned during study
• •Any other condition classed as unsuitable for study participation by the medical executive director
• •prior convictions (objectionable criminal record)
• •Metal implants or other osteosynthesis material
• •Pacemaker
• •Claustrophobia