Study of Fat Tissue's Ability to Take up Sugar in the Obese Population

Inclusion Criteria

• •All subjects
• •Age: greater than or equal to 18 years but \<65 years
• •Weight stable (i.e., ±2 kg for at least 3 months)
• •Sedentary (less than 1 hour of structured exercise per week)
• •No evidence of significant organ system dysfunction or disease (e.g., diabetes, impaired kidney function, cancer, etc.)
• •Metabolically Normal Lean
• •BMI greater than or equal to 18.5 but \<25.0 kg/m2
• •Fasting blood glucose: \<100 mg/dl
• •Blood glucose 2 h after an OGTT: \<140 mg/dl
• •HbA1c \<5.7 %.
• •Metabolically Normal Obese, likely insulin sensitive
• •BMI greater than or equal to 30.0 but \<45.0 kg/m2
• •Fasting blood glucose: \<100 mg/dl
• •Fasting insulin: \<20 mU/l
• •Blood glucose 2 h after an OGTT: \<140 mg/dl
• •HbA1c \<5.7 %.
• •Metabolically Abnormal Obese, likely insulin resistant
• •BMI greater than or equal to 30.0 but \<45.0 kg/m2
• •Fasting blood glucose ≥100 mg/dl or blood glucose 2 h after an OGTT ≥140 mg/dl or fasting insulin \>20 µU/mL or HbA1c \>5.7 %.
• •Metabolically Abnormal Lean
• •BMI greater than or equal to 18.5 but \<25.0 kg/m2
• •Fasting blood glucose ≥100 mg/dl or blood glucose 2 h after an OGTT ≥140 mg/dl or fasting insulin \>20 µU/mL or HbA1c \>5.7 %.