An Exploratory Study of DS-8500a on Beta Cell Function Using Hyperglycemic Clamp

Exclusion Criteria

• •Patients with type 1 diabetes mellitus or with a history of diabetic coma, precoma, or ketoacidosis
• •Patients receiving or requiring treatment with insulin
• •Patients with a body mass index (BMI) of \< 18.5 kg/m2 or ≥ 35.0 kg/m2
• •Patients with clinically evident renal impairment (estimated glomerular filtration rate \[eGFR\] of \< 45 mL/min per 1.73 m2) or clinically significant renal disease
• •Patients with fasting plasma glucose ≥ 240 mg/dL