Physiological and Cognitive Biomarkers for Ketamine's Antidepressant Effects

Exclusion Criteria

• •1. delirium or dementia diagnosis,
• •2. unstable medical illness or clinically significant laboratory results,
• •3. history of clinically significant cardiovascular disease or electrocardiogram (EKG) findings, or medical conditions that put the patient at risk for possible cardiac side effects (e.g., requirement of cardiac pacemaker) or alter brain morphology (e.g., recent head trauma, post intracranial surgery, intracranial mass or bleed or unstable sleep apnea), or a blood pressure \>140/95 mmHg at Screening,
• •4. history of multiple adverse drug reactions,
• •5. current/past history of psychotic disorders, history of out-of-body feelings or derealization,
• •6. active substance use disorders (except nicotine and caffeine) within the past six months or past history of ketamine/PCP (phencyclidine) abuse (we will confirm this with collateral information from their doctor if necessary),
• •7. requirement of excluded medications that may interact with ketamine,
• •8. caffeine or nicotine use within 1 hour of psychophysiology testing, or alcohol use within 1 day of testing,
• •9. pregnancy, breastfeeding, or unacceptable means of birth control (females only)
• •10. clinically significant hearing impairment,
• •11. current serious suicidal or homicidal risk,
• •12. concurrent participation in other research studies involving medications or other treatments,
• •13. narrow angle glaucoma,
• •14. acute intermittent porphyria history,
• •15. history of seizures in the past 6 months, regardless of seizure type,
• •16. hyperthyroidism or untreated hypothyroidism,
• •17. airway instability or pulmonary disease with hypercarbia, or
• •18. current or past cubital or carpal tunnel syndrome.