tDCS Effects on Resisting Smoking: Dose Ranging Study

Exclusion Criteria

• •Alcohol/Drugs:
• •1. History or current diagnosis or treatment for alcohol or drug abuse (as reported during phone screen);
• •2. Positive breath alcohol concentration test (BrAC \>0.01) at any study visit. a. Participants testing positive for breath alcohol with a reading equal to or greater than .08 (the legal driving limit) or who are visibly impaired will be instructed not to drive themselves home after the appointment. If a participant needs to use a phone to call for a safe ride home, an office telephone will be made available to the participant.
• •Medication:
• •Current use or recent discontinuation (within the last 14 days at the time of Intake) of:
• •1. Smoking cessation medication (e.g., Zyban, Wellbutrin, Wellbutrin SR, Chantix);
• •2. Anti-psychotic medications;
• •3. Nicotine replacement therapy (NRT);
• •4. GABAergic medications;
• •5. Glutamatergic medications;
• •6. Any medication that could compromise participant safety as determined by the Principal Investigator and/or Study Physician.
• •Daily use of:
• •7. Opiate-containing medications for chronic pain;
• •8. Benzodiazepines.
• •Medical/Neuropsychiatric:
• •1. Women who are pregnant, planning a pregnancy, and/or breast feeding. All female subjects will complete a urine pregnancy test at the intake visit and preceding all brain stimulation sessions (4 urine pregnancy tests in total);
• •2. History of epilepsy or a seizure disorder;
• •3. History of stroke;
• •4. Self-reported history of brain or spinal tumor;
• •5. Self-reported history or current diagnosis of psychosis, including schizophrenia, mania, bipolar disorder, major depression (subjects with a history of major depression but in remission for past 6 months are eligible).
• •tDCS-related:
• •1. Self-report of metallic objects in the face or head other than dental apparatus (e.g. braces, fillings, and implants);
• •2. Self-report of pacemakers or implantable cardioverter-defibrillator (ICD).
• •3. Self-report of any skull fracture or opening.
• •General Exclusion:
• •1. Any medical condition, illness, disorder, or concomitant medication that could compromise participant safety or treatment, as determined by the Principal Investigator;
• •2. Low or borderline intellectual functioning - determined by a score of less than 90 on the Shipley Institute of Living Scale (SILS) (administered at Intake Visit). The SILS correlates with the Wechsler Adult Intelligence Scale-Revised (WAIS-R) Estimated IQ Test;
• •3. Inability to provide informed consent or complete any of the study tasks as determined by the Principal Investigator.