Buspirone Treatment of Iatrogenic Dyskinesias in Advanced Parkinson' Disease

Exclusion Criteria

• •Female subjects : pregnant or lactating
• •Atypical parkinsonian syndrome
• •Weight less than 40 Kgs
• •Mini-Mental State Examination (MMSE) less than 24
• •The subject is participating in another clinical study within the past 12 weeks
• •Planned participation in another therapeutic clinical study
• •Previous treatment with buspirone, less than 6 months before Week 0
• •Known allergy to buspirone
• •Known lactose intolerance
• •Clinically significant illness that might interfere with the study
• •Dementia or other psychiatric illness
• •Drug or alcohol abuse replaced by Substance use disorder (alcohol i.e. \> 3 drinks per day for men and \> 2 drinks per day for women,drug, medicinal product) (amendment n°1)
• •Legal incapacity or limited legal capacity
• •Deep brain stimulation performed less than 12 months before protocol initiation, or unstable parameters of stimulation 4 weeks before week 0
• •Severe renal and / or hepatic impairment
• •History of seizures or epilepsy