pregnant woman or breastfeeding

patient participating to other biomedical research

patient who have participated to other biomedical research within the past 3 months

patient refusing to sign the inform consent

Patient who stopped smoking since less than 12 months

Pathological state related to obstructive distal airway damage

Broncho-pulmonary infectious disease within the past 4 weeks

Solid tumor curated by chemotherapy or chest radiotherapy

Chronic respiratory disease

Asthma exacerbation within the past 3 months

Oral or systemic corticotherapy within the past 3 months

AVAD: Asthma With Small Airways Dysfunction